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Patents

JW Creagene의 보유기술 특허
NO Patents
1 Method of Preparing Dendritic Cell, Dendritic Cell Prepared by the Same and Use Thereof
2 Method for Preparing Dendritic Cell With Increased Expression of Specific Genes And Composition For Preventing Or Treating Autoimmune Diseases Comprising Dendritic Cell Prepared By The Same
3 IFN-α Fusion Protein Comprising Interferon-α Linked to Cytoplasmic Transduction Peptide and Polyethylene glycol
4 A composition for maturation of Dendritic cell and a method of Preparing antigen-specific Dendritic Cell using the same
5 Method for preparing dendritic cells having potential to induce cancer specific immune response, pharmaceutical composition and kit for treating or preventing cancer or inhibiting cancer metastasis comprising the same
6 IFN-α fused protein having interferon-α and cytoplasmic transduction peptide
7 Method for preparing prostate acid phosphatase antigen for pulsing dendritic cells for prostate cancer immunotherapy
8 Autologous dendritic cell mediated by photodynamic therapy having the ability to suppress the growth of tumor
9 Pharmaceutical compositions for treating rheumatoid arthritis comprising semi-mature dendritic cell
10 Novel use of MLN51 gene and protein
11 Animal models carrying tumors expressing human liver cancer-specific antigen and method for analyzing prevention and treatment efficacy of dendritic cells-derived immunotherapeutics using the above
12 Animal models carrying tumors expressing human prostate cancer-specific antigen and method for analyzing prevention and treatment efficacy of dendritic cells-derived immunotherapeutics using the above
13 Method for Measuring Effectively the Activity of Cytotoxic T Lymphocyte in Human and Out-bred Animals
14 Novel Recombinant Sabin Type 1 Poliovirus Vector and Improved Recombinant Polio Vaccine Composition Using the Same
15 Novel Dendritic Cell-Specific Polynucleotides andMicroarray Comprising the Same
16 Novel recombinant poliovirus vectors and vaccine compositions capable of inducing cytotoxic T lymphocytes
17 Cytoplasmic Transduction Peptides and Uses thereof
18 Method for prepraring mature dendritic cell-vaccine for immunotherapy
19 Transgenic Escherichia coli transformed with pGM-CSF vector expressing recombinant mouse granulocyte-macrophage colony stimulating factor and method for mass production of the recombinant protein
20 The preparation method of recombinant human interleukin-4
21 Pharmaceutical Compositions Comprising Dendritic Cells for Immunotherapy of Autoimmune Disease and Treatment Methods Using the Same
22 Method for Improving a Genetic Stability for the Insert in (+)-Single-Stranded RNA Virus Recombinant Vectors
23 SABIN TYPE 1 RECOMBINANT POLIOVIRUS VECTOR

Theses

JW Creagene의 연구논문
NO Research Papers
1 Increased synthesis of hyaluronic acid by enhanced penetration of CTP-EGF recombinant in human keratinocytes
J Cosmet Dermatol 18(5):1539-1545 (2019)
2 A phase I/IIa study of adjuvant immunotherapy with tumour antigen-pulsed dendritic cells in patients with hepatocellular carcinoma
Br J Cancer 113(12)1666-76 (2015)
3 Dendritic cell-based therapeutic cancer vaccines: past, present and future.
Clin Exp Vaccine Res 3(2):113-6 (2014)
4 Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 inductionin astrocytes.
Toxicol Appl Pharmacol 280(1):42-52 (2014)
5 Egr2 induced during DC development acts as an intrinsic negative regulator of DC immunogenicity
Eur. J. Immunol 43(9):2484-96 (2013)
6 New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses
EMBO reports 11(5):393-9 (2010)
7 Semi-mature DC are immunogenic and not tolerogenic when inoculated at a high dose in collagen-induced arthritis mice
Eur J Immunol. 39(5):1334-43 (2009)
8 PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53
Proc Natl Acad Sci USA. 106(19):7852-7 (2009)
9 Tumor-mediated down-regulation of MHC class II in DC development is attributable to the epigenetic control of the CIITA type I promoter
Eur J Immunol. 39(3):858-68 (2009)
10 FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis
FEBS J. 275(14):3546-55 (2008)
11 The double-strand RNA-dependent protein kinase PKR plays a significant role in a sustained ER stress-induced apoptosis
FEBS Letter 581(22):4325-32 (2007)
12 Phase I/II Study of Immunotherapy Using Autologous Tumor Lysate-pulsed Dendritic Cells Patients with Metastatic Renal Cell Carcinoma
Clin. Cancer Immunol. 125(3):257-67 (2007)
13 DC immunotherapy is highly effective for the inhibition of tumor metastasis or recurrence, although it is not efficient for the eradication of established solid tumors
Cancer Immunol. Immunother. 56(11):1817-29 (2007)
14 MLN51 and GM-CSF involvement in the proliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis
Arthritis Res Therapy
(2006. 11.14, On-line published) 8(6):R170
15 Cytoplasmic transduction peptide (CTP): New approach for the delivery of biomolecules into cytoplasm in vitro and in vivo
Exp. Cell Res. 312(8):1277-88 (2006)
16 MAPK regulation and caspase activation are required in DMNQ S-52 induced apoptosis in Lewis lung carcinoma cells
Cancer Lett. 233(1)57-67 (2006)
17 Newly Designed Six-Membered Azasugar Nucleotide-Containing Phosphorothioate Oligonucleotides as Potent Human Immunodeficiency Virus Type 1 Inhibitors
Antimicrobial Agents and Chemoth 49(10):4110-20 (2005)
18 Present and Future of Dendritic cell-based Tumor Vaccine
J Tissue Eng Regen Med 2:251-63 (2005)
19 Shiquandabutangjiaweibang inhibits tumor metastasis and angiogenesis via regulation of topoisomerase-1
J of Ethnopharmacol. 98(1-2):157-62 (2005)
20 Current trends and future in Dendritic cell-based tumor vaccine
Trend in Health Industry and Technol. 20:17-29 (2004)
21 In vitro mesengenic potential of human umbilical cord blood-derived mesenchymal stem cells
Biochem. Biophys. Res. Comm. 321(1):102-8 (2004)
22 Human cytomegalovirus induces apoptosis in promonocyte THP-1 cells but not in promyeloid HL-60 cells
Virus Res. 94(2):67-77 (2003)
23 Identification of the genes differentially expressed in human dendritic cell subsets by cDNA subtraction and microarray analysis
Blood 100(5):1742 -54 (2002)
24 Novel Design Architecture for Genetic Stability of Recombinant Poliovirus: the Manipulation of G/C Contents and Their Distribution Patterns Increases the Genetic Stability of Inserts in a Poliovirus-Based RPS-Vax Vector System
J. Virol. 76(4):1649-62 (2002)
25 In vitro binding analysis of Hepatitis B virus-Pre-S derived putative helper T-cell epitopes to MHC class II molecules using stable HLA-DRB10405/-DRA0101 transfected cells
IUBMB Life 50(6):379-84 (2001)
26 Prevention of Encephalomyocarditis Virus–Induced Diabetes by Live Recombinant Mycobacterium bovis Bacillus Calmette-Guérin in Susceptible Mice
Diabetes 49(9):1459-67 (2000)
27 Truncated Form of Importin α Identified in Breast Cancer Cell Inhibits Nuclear Import of p53
J. Biol. Chem. 275(30):23139-45 (2000)