> 研究開発 > 研究成果特許
| NO | 保有特許技術 |
|---|---|
| 1 | 樹状細胞の製造方法、これにより製造された樹状細胞及びその用途 |
| 2 | 特定遺伝子発現が増加した樹状細胞の製造方法及びこれを利用して製造された樹状細胞を含む免疫調節の治療または予防用組成物 |
| 3 | 細胞質残留性細胞膜透過ペプチド及びポリエチレングリコールが結合したインターフェロンアルファ融合蛋白質 |
| 4 | 樹状細胞成熟化組成物及びこれを利用して抗原特異的樹状細胞を製造する方法 |
| 5 | 癌特異免疫反応誘導能を有する樹状細胞の製造方法、この樹状細胞を含む癌の予防、治療または転移抑制用薬剤学的組成物及びキット |
| 6 | インターフェロンアルファ及び細胞質残留性細胞膜透過ペプチドを含むIFN-α融合蛋白質 |
| 7 | 前立腺癌免疫治療用樹状細胞製造のためのPAP抗原の製造方法 |
| 8 | 腫瘍成長抑制能を有する光力動性治療媒介の自己由来樹状細胞 |
| 9 | 準成熟樹状細胞を含む関節リウマチ治療用薬剤学的組成物 |
| 10 | MLN51遺伝子または蛋白質の新規用途 |
| 11 | 人間肝臓癌動物モデル及びこれを用いた樹状細胞由来肝臓癌免疫治療剤の予防及び治療効果を分析する方法 |
| 12 | 人間前立腺癌の動物モデル及びこれを利用した樹状細胞-由来前立腺癌免疫治療剤の予防及び治療効能を分析する方法 |
| 13 | 人間及び非近交系動物で細胞毒性Tリンパ球の活性を効果的に測定する方法 |
| 14 | 組換えザビン1型ポリオウイルスベクター及びこれを利用した改良型の組換え小児麻痺ワクチン組成物 |
| 15 | 新規の樹状細胞-特異ポリヌクレオチド及びこれを含むマイクロアレイ |
| 16 | 新規のCTL誘導用組換えポリオウイルスベクター及びワクチン組成物 |
| 17 | 細胞質残留性細胞膜透過ペプチド及びその用 |
| 18 | 免疫治療用の成熟した樹状細胞ワクチンの製造方法 |
| 19 | マウス顆粒球マクロファージコロニー促進因子発現ベクターpGM-CSFで形質転換された大腸菌及び上記マウス顆粒球マクロファージコロニー促進因子の大量生産方法 |
| 20 | 組換えヒトインターロイキン-4の製造方法 |
| 21 | 樹状細胞を含む免疫調節の治療用薬剤学的組成物及びこれを用いた治療方法 |
| 22 | (+)-単一鎖RNA組換えベクター内挿入序列の遺伝的安定性を増加させる方法 |
| 23 | 組換えサビン1型ポリオウイルスベクター |
論文
| NO | 研究論文 |
|---|---|
| 1 | A phase I/IIa study of adjuvant immunotherapy with tumour antigen-pulsed dendritic cells in patients with hepatocellular carcinoma Br J Cancer 113(12)1666-76 (2015) |
| 2 | Dendritic cell-based therapeutic cancer vaccines: past, present and future. Clin Exp Vaccine Res 3(2):113-6 (2014) |
| 3 | Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 inductionin astrocytes. Toxicol Appl Pharmacol 280(1):42-52 (2014) |
| 4 | Egr2 induced during DC development acts as an intrinsic negative regulator of DC immunogenicity Eur. J. Immunol 43(9):2484-96 (2013) |
| 5 | New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses EMBO reports 11(5):393-9 (2010) |
| 6 | Semi-mature DC are immunogenic and not tolerogenic when inoculated at a high dose in collagen-induced arthritis mice Eur J Immunol. 39(5):1334-43 (2009) |
| 7 | PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53 Proc Natl Acad Sci USA. 106(19):7852-7 (2009) |
| 8 | Tumor-mediated down-regulation of MHC class II in DC development is attributable to the epigenetic control of the CIITA type I promoter Eur J Immunol. 39(3):858-68 (2009) |
| 9 | FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis FEBS J. 275(14):3546-55 (2008) |
| 10 | The double-strand RNA-dependent protein kinase PKR plays a significant role in a sustained ER stress-induced apoptosis FEBS Letter 581(22):4325-32 (2007) |
| 11 | Phase I/II Study of Immunotherapy Using Autologous Tumor Lysate-pulsed Dendritic Cells Patients with Metastatic Renal Cell Carcinoma Clin. Cancer Immunol. 125(3):257-67 (2007) |
| 12 | DC immunotherapy is highly effective for the inhibition of tumor metastasis or recurrence, although it is not efficient for the eradication of established solid tumors Cancer Immunol. Immunother. 56(11):1817-29 (2007) |
| 13 | MLN51 and GM-CSF involvement in the proliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis Arthritis Res Therapy (2006. 11.14, On-line published) 8(6):R170 |
| 14 | Cytoplasmic transduction peptide (CTP): New approach for the delivery of biomolecules into cytoplasm in vitro and in vivo Exp. Cell Res. 312(8):1277-88 (2006) |
| 15 | MAPK regulation and caspase activation are required in DMNQ S-52 induced apoptosis in Lewis lung carcinoma cells Cancer Lett. 233(1)57-67 (2006) |
| 16 | Newly Designed Six-Membered Azasugar Nucleotide-Containing Phosphorothioate Oligonucleotides as Potent Human Immunodeficiency Virus Type 1 Inhibitors Antimicrobial Agents and Chemoth 49(10):4110-20 (2005) |
| 17 | Present and Future of Dendritic cell-based Tumor Vaccine J Tissue Eng Regen Med 2:251-63 (2005) |
| 18 | Shiquandabutangjiaweibang inhibits tumor metastasis and angiogenesis via regulation of topoisomerase-1 J of Ethnopharmacol. 98(1-2):157-62 (2005) |
| 19 | Current trends and future in Dendritic cell-based tumor vaccine Trend in Health Industry and Technol. 20:17-29 (2004) |
| 20 | In vitro mesengenic potential of human umbilical cord blood-derived mesenchymal stem cells Biochem. Biophys. Res. Comm. 321(1):102-8 (2004) |
| 21 | Human cytomegalovirus induces apoptosis in promonocyte THP-1 cells but not in promyeloid HL-60 cells Virus Res. 94(2):67-77 (2003) |
| 22 | Identification of the genes differentially expressed in human dendritic cell subsets by cDNA subtraction and microarray analysis Blood 100(5):1742 -54 (2002) |
| 23 | Novel Design Architecture for Genetic Stability of Recombinant Poliovirus: the Manipulation of G/C Contents and Their Distribution Patterns Increases the Genetic Stability of Inserts in a Poliovirus-Based RPS-Vax Vector System J. Virol. 76(4):1649-62 (2002) |
| 24 | In vitro binding analysis of Hepatitis B virus-Pre-S derived putative helper T-cell epitopes to MHC class II molecules using stable HLA-DRB10405/-DRA0101 transfected cells IUBMB Life 50(6):379-84 (2001) |
| 25 | Prevention of Encephalomyocarditis Virus–Induced Diabetes by Live Recombinant Mycobacterium bovis Bacillus Calmette-Guérin in Susceptible Mice Diabetes 49(9):1459-67 (2000) |
| 26 | Truncated Form of Importin α Identified in Breast Cancer Cell Inhibits Nuclear Import of p53 J. Biol. Chem. 275(30):23139-45 (2000) |